My son who has TS, was also born with a congentical heart defect, transposition of the great arteries. He had an arterial switch at birth to have it corrected. My questions is, if we should decide to use meds at some point, are there studies on these meds effect on the heart? In particular congenital heart defect children? My son currently has very loud, high pitched vocal tics that get a lot of attention, along with motor tics. He experiences headaches from neck jerks, is in middle school, and handling it OKAY, honor student. So his main issues are headaches, and social issues. Is there hope for him using any meds with his heart situation? Thank you.

My 38 year old adult son has suffered from depression and since his early twenties. With Zoloft and close family support, he has managed to lead what society considers a very successful life. Like me, he has also suffered from relatively mild TS since childhood. His TS has only flared up after a situation which severely stressed him last summer and the TS has progressively gotten worse. He went on Tenex about 6 weeks ago and, it not only did nothing for his TS, but, since taking it, his depression flared up like is was at it’s worst. This included anger, rage, irrationality, severe tension headaches, overeating, accomplishing less and other manisfestations. I’ve read that Tenex can cause depression. Can you tell me: a) how strong is that connection (statistically or otherwise), and b) is Tenex known to be more likely to cause depression in a person who already has tendencies toward depression?